Entry to the citric acid cycle involves the generation of acetyl CoA. The enzyme that catalyzes the production of acetyl CoA is _. This enzyme is negatively regulated by _ in a high-energy charge situation.

In the Krebs cycle, pyruvic acid from glycolysis undergoes an oxidative decarboxylation process through the action of the pyruvate dehydrogenase enzyme found within the mitochondria of eukaryotes, it reacts with coenzyme A (CoA).

The result of this reaction is the production of acetylcoenzyme A (acetylCoA) and a carbon dioxide (CO₂) molecule.

When acetyl CoA and ATP are at high concentrations (in addition to the increased NADH / NAD⁺ ratio), pyruvate carboxylase production is stimulated.

This process will eventually generate oxalacetic acid for gluconeogenesis (conversion of pyruvate to glucose).

By increasing oxalacetic acid concentrations, pyruvate dehydrogenase is eventually inhibited by a negative feedback mechanism.

In other words, as energy levels increase, the higher the pyruvate carboxylase production, and therefore the greater the inhibition of pyruvate dehydrogenase.

Entry to the citric acid cycle involves the generation of acetyl CoA. The enzyme that catalyzes the production of acetyl CoA is _____. This enzyme is negatively regulated by _____ in a high-energy charge situation.

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Entry to the citric acid cycle involves the generation of acetyl CoA. The enzyme that catalyzes the production of acetyl CoA is _. This enzyme is negatively regulated by _ in a high-energy charge situation.